Immunophenotypic Differences in Cerebrospinal Fluid and Peripheral Blood Demonstrating Cancer Heterogenicity in Acute Myeloid Leukemia Patient.
Publication/Presentation Date
1-1-2022
Abstract
A diagnosis of acute myeloid leukemia involving the central nervous system (CNS) can be confirmed through cerebrospinal fluid (CSF) and serum flow cytometry. These two detection methods should demonstrate the same immunophenotype due to hematogenous dissemination. Here, we reported a 65-year-old male diagnosed with CNS leukemia with differing immunophenotypes between CSF and peripheral blood. This immunophenotypic shift may suggest leukemic migration within the blood-brain barrier. In addition, the case highlights the concept of leukemic heterogeneity and the importance of considering cancer heterogeneity when analyzing a tumor's genetic profile and selecting therapy for patients.
Volume
15
Issue
3
First Page
874
Last Page
880
ISSN
1662-6575
Published In/Presented At
Edirisuriya, C., Jeurkar, C., Nazir, B., Belovsky, M., & Kasner, M. (2022). Immunophenotypic Differences in Cerebrospinal Fluid and Peripheral Blood Demonstrating Cancer Heterogenicity in Acute Myeloid Leukemia Patient. Case reports in oncology, 15(3), 874–880. https://doi.org/10.1159/000526571
Disciplines
Medicine and Health Sciences
PubMedID
36825101
Department(s)
Hematology-Medical Oncology Division
Document Type
Article