Targeting vascular endothelial growth factor receptor in thyroid cancer: the intracellular and extracellular implications.
Publication/Presentation Date
2-1-2010
Abstract
Our understanding of the molecular pathophysiology of differentiated thyroid cancer (DTC) has developed considerably over the last 10 years. Aberrant signaling through B-Raf and Akt has been implicated in the tumorigenesis of DTC. Moreover, these highly vascular tumors have proven to be sensitive to the inhibition of vascular endothelial growth factor receptor (VEGFR-2). It is likely that the multikinase inhibitors, sorafenib, sunitinib, axitinib, and motesanib, whose targets include VEGFR-2, exert their effects primarily through inhibition of endothelial cells. However, as VEGFR-2 is expressed on DTC cells, these compounds may have direct antitumor action. This review will discuss the key signaling pathways involved in thyroid cancer and their implications for targeted therapy.
Volume
16
Issue
3
First Page
778
Last Page
783
ISSN
1557-3265
Published In/Presented At
Keefe, S. M., Cohen, M. A., & Brose, M. S. (2010). Targeting vascular endothelial growth factor receptor in thyroid cancer: the intracellular and extracellular implications. Clinical cancer research : an official journal of the American Association for Cancer Research, 16(3), 778–783. https://doi.org/10.1158/1078-0432.CCR-08-2743
Disciplines
Medicine and Health Sciences
PubMedID
20103668
Department(s)
Hematology-Medical Oncology Division
Document Type
Article