Lack of BRAF mutations in hyalinizing trabecular neoplasm.
Publication/Presentation Date
7-25-2006
Abstract
The hyalinizing trabecular neoplasm (HTN) of the thyroid is an unusual and controversial lesion. Some consider it a peculiar type of papillary thyroid carcinoma (PTC) because of its nuclear features and presence of psammoma bodies. Others consider it an adenoma. Molecular studies have found RET/PTC translocations in some examples, supporting HTN as a PTC; however mutations in BRAF (another marker for PTC) have not been found. We report two cases of classic HTN and a case of trabecular PTC and show BRAF mutations in the latter and not in HTN. Trabecular growth pattern is insufficient for a diagnosis of HTN and lesions with such a pattern and nuclear features of PTC are cancers. Morphologically classic HTN are not associated with metastatic potential and should be considered adenomas.
Volume
3
First Page
17
Last Page
17
ISSN
1742-6413
Published In/Presented At
Baloch, Z. W., Puttaswamy, K., Brose, M., & LiVolsi, V. A. (2006). Lack of BRAF mutations in hyalinizing trabecular neoplasm. CytoJournal, 3, 17. https://doi.org/10.1186/1742-6413-3-17
Disciplines
Medicine and Health Sciences
PubMedID
16867191
Department(s)
Hematology-Medical Oncology Division
Document Type
Article