Reconstituting donor T cells increase their biomass following hematopoietic stem cell transplantation.

Authors

Kevin A Leslie
Mahmood Rasheed
Roy T Sabo
Catherine C Roberts
Amir Toor MD, Lehigh Valley Health NetworkFollow
Jason Reed

Publication/Presentation Date

5-29-2018

Abstract

In this study, we used a rapid, highly-sensitive, single-cell biomass measurement method, Live Cell Interferometry (LCI), to measure biomass in populations of CD3 + T cells isolated from hematopoietic stem cell transplant (SCT) patients at various times pre- and post-transplant (days 0-100). CD3 + T cell 'mass spectra' were obtained from five autologous and 20 allogenic transplant recipients. We found a pronounced rise in median T cell biomass (+25%; p

Volume

143

Issue

11

First Page

2479

Last Page

2485

ISSN

1364-5528

Published In/Presented At

Leslie, K. A., , Rasheed, M., , Sabo, R. T., , Roberts, C. C., , Toor, A. A., , & Reed, J., (2018). Reconstituting donor T cells increase their biomass following hematopoietic stem cell transplantation. The Analyst, 143(11), 2479–2485. https://doi.org/10.1039/c8an00148k

Disciplines

Medicine and Health Sciences

PubMedID

29589850

Department(s)

Department of Medicine, Hematology-Medical Oncology Division

Document Type

Article