Reconstituting donor T cells increase their biomass following hematopoietic stem cell transplantation.
In this study, we used a rapid, highly-sensitive, single-cell biomass measurement method, Live Cell Interferometry (LCI), to measure biomass in populations of CD3 + T cells isolated from hematopoietic stem cell transplant (SCT) patients at various times pre- and post-transplant (days 0-100). CD3 + T cell 'mass spectra' were obtained from five autologous and 20 allogenic transplant recipients. We found a pronounced rise in median T cell biomass (+25%; p
Published In/Presented At
Leslie, K. A., , Rasheed, M., , Sabo, R. T., , Roberts, C. C., , Toor, A. A., , & Reed, J., (2018). Reconstituting donor T cells increase their biomass following hematopoietic stem cell transplantation. The Analyst, 143(11), 2479–2485. https://doi.org/10.1039/c8an00148k
Medicine and Health Sciences
Department of Medicine, Hematology-Medical Oncology Division