A dynamical systems perspective on chimeric antigen receptor T-cell dosing.

Publication/Presentation Date

3-1-2019

Abstract

Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. However, the mechanism driving proliferation in CAR T cells is distinct from conventional T cells. As such there are quantitative differences in the antigen response of these engineered cells when compared with conventional T cells. In this perspective paper the logistic equation of growth is used to develop a mathematical basis for understanding the difference between CAR T cell and conventional T cell response to antigen burden.

Volume

54

Issue

3

First Page

485

Last Page

489

ISSN

1476-5365

Disciplines

Medicine and Health Sciences

PubMedID

30171224

Department(s)

Department of Medicine, Hematology-Medical Oncology Division

Document Type

Article

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