Expression of messenger RNA for insulin-like growth factors and insulin-like growth factor binding proteins by experimental breast cancer and normal breast tissue in vivo.
Publication/Presentation Date
3-1-1992
Abstract
We report the expression of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) by breast cancer cells and normal breast tissue in vivo. N-nitrosomethyl-urea (NMU)-induced rat mammary tumors synthesize mRNAs for IGF-II and IGFBP-2, -3, and -4. In contrast, normal lactating breast contains only IGFBP-2 and IGF-II messages; IGFBP-3 and -4 mRNAs are absent in this tissue. IGF-I and IGFBP-1 mRNAs are not expressed in either NMU tumors or in normal breast. This is the first report of in vivo expression of IGFBPs and IGF-II messages in breast tumors.
Volume
130
Issue
3
First Page
1744
Last Page
1746
ISSN
0013-7227
Published In/Presented At
Manni, A., Wei, L., Badger, B., Zaenglein, A., Leighton, J., Shimasaki, S., & Ling, N. (1992). Expression of messenger RNA for insulin-like growth factors and insulin-like growth factor binding proteins by experimental breast cancer and normal breast tissue in vivo. Endocrinology, 130(3), 1744–1746. https://doi.org/10.1210/endo.130.3.1371457
Disciplines
Medicine and Health Sciences
PubMedID
1371457
Department(s)
Department of Medicine Faculty
Document Type
Article