A systematic review of adult animal models investigating ECMO use for ARDS: where to from here.
Publication/Presentation Date
7-18-2025
Abstract
BACKGROUND: Controlled clinical trials investigating ongoing questions about extracorporeal membrane oxygenation (ECMO) for patients with the acute respiratory distress syndrome (ARDS), including what the optimal mechanical ventilation (MV) tidal volume (TV) strategies are and whether ECMO potentiates injurious host responses, are difficult. We therefore conducted a systematic literature search and review to characterize studies investigating ECMO in adult animal lung injury models and to determine whether they inform these questions.
METHODS: A systematic literature search with relevant search terms was conducted of four data bases through 2/2/24.
RESULTS: Forty-five studies met inclusion criteria, and most parameters examined were represented similarly in studies with (n = 24) or without (n = 21) severe ARDS PaO
Volume
13
Issue
1
First Page
74
Last Page
74
ISSN
2197-425X
Published In/Presented At
Alnababteh, M., Cui, X., Jeakle, M., Li, Y., Terry, N., Gamble, T., Sun, J., Kanth, S., Eichacker, P. Q., & Torabi-Parizi, P. (2025). A systematic review of adult animal models investigating ECMO use for ARDS: where to from here. Intensive care medicine experimental, 13(1), 74. https://doi.org/10.1186/s40635-025-00781-5
Disciplines
Medicine and Health Sciences
PubMedID
40679770
Department(s)
Department of Medicine
Document Type
Article