Effects of antibiotics on polymorphonuclear leukocyte chemiluminescence and chemotaxis.
Publication/Presentation Date
10-1-1983
Abstract
Polymorphonuclear leukocyte chemiluminescence and chemotaxis assays were performed on cells obtained from normal individuals and patients with defined defects in chemotaxis or chemiluminescence. After in-vitro pre-incubation with trimethoprim/sulphamethoxazole, its separate components, clindamycin and cefotaxime, normal cells showed some enhancement in chemotaxis and significant increase in chemiluminescence. There was an even more marked increase in chemotaxis when these antibiotics were incubated with cells from patients with leukocyte chemotaxic defects. When the cells from patients with chemiluminescence defects were pre-incubated with these antibiotics, there was also substantial enhancement in chemiluminescence.
Volume
12 Suppl C
First Page
35
Last Page
38
ISSN
0305-7453
Published In/Presented At
Oleske, J. M., de la Cruz, A., Ahdieh, H., Sorvino, D., La Braico, J., Cooper, R., Singh, R., Lin, R., & Minnefor, A. (1983). Effects of antibiotics on polymorphonuclear leukocyte chemiluminescence and chemotaxis. The Journal of antimicrobial chemotherapy, 12 Suppl C, 35–38. https://doi.org/10.1093/jac/12.suppl_c.35
Disciplines
Medicine and Health Sciences
PubMedID
6196344
Department(s)
Department of Medicine
Document Type
Article