Hypoxia-induced hypomyelination in the developing brain is mammalian target of rapamycin-4E-binding protein-1 signaling dependent.
Publication/Presentation Date
4-16-2008
Abstract
We hypothesized that changes in the expression levels of genes in the mammalian target of rapamycin are involved in the hypoxia-induced growth retardation in the brain including hypomyelination. Microarray and proteomic studies showed a 2.3-fold increase in the expression levels of eukaryotic translation initiation factor 4E-binding protein-1 and a 3-fold decrease in the levels of FK506-binding protein-1 in a neonatal model of hypoxia, indicating a signal transduction impairment through mammalian target of rapamycin (mTOR). Analysis of hypoxic brain showed a marked decrease in the phosphorylation levels of 4E-binding protein-1, suggesting a reduction of mTOR activity. These data suggest that suppression of mTOR may be the mechanism underlying hypoxia-induced hypomyelination observed in the developing brain.
Volume
19
Issue
6
First Page
635
Last Page
639
ISSN
0959-4965
Published In/Presented At
Bilali, F., Kumar, P., Feerick, J., Berezin, S., & Farahani, R. (2008). Hypoxia-induced hypomyelination in the developing brain is mammalian target of rapamycin-4E-binding protein-1 signaling dependent. Neuroreport, 19(6), 635–639. https://doi.org/10.1097/WNR.0b013e3282fa701c
Disciplines
Medicine and Health Sciences
PubMedID
18382277
Department(s)
Department of Medicine
Document Type
Article