Validation of epistaxis severity score for hereditary hemorrhagic telangiectasia in Japan.
Publication/Presentation Date
6-1-2022
Abstract
OBJECTIVE: This study aimed to assess the health-related QoL (HR-QoL) of patients with hereditary hemorrhagic telangiectasia (HHT), with emphasis on the role/social aspects, and validate the Japanese version of the epistaxis severity score (ESS) in these patients.
METHODS: The Japanese version of the ESS was created through forward and reverse translation, and consultation with the original author. A validation analysis was performed by comparing ESS severity with the invasiveness of previous treatments for epistaxis and assessing the correlation between the ESS and HR-QoL. Medical history forms, ESS questionnaires, and the Medical Outcomes Study Short Form 36 (SF-36) were distributed to participants with HHT in August 2020. The relation between the ESS and summary scores of SF-36 was assessed by performing analysis of variance and Spearman's correlation.
RESULTS: In total, 73 participants were included in this study. The average ESS was 5.02; there were mild (32.9%), moderate (45.2%), and severe (21.9%) epistaxis groups. Patients with higher ESS received a significantly more invasive treatment (Fisher's exact test, p < 0.05). The ESS was also negatively correlated with the physical component score (PCS) (r = -0.489, p < 0.001). Comorbid liver and gastrointestinal arteriovenous malformations significantly reduced the PCS (p < 0.05). Multiple regression analysis revealed that the ESS was a significant variable (p < 0.01). The role/social component score was significantly lower in the severe ESS group than in the mild or moderate group.
CONCLUSION: The Japanese version of the ESS was considered valid and may be useful as an outcome measure of future HHT-associated epistaxis trials in Japan.
Volume
49
Issue
3
First Page
415
Last Page
420
ISSN
1879-1476
Published In/Presented At
Hayama, M., Maeda, Y., Shikina, T., Tatehara, S., Inokuchi, G., Hoag, J. B., Sato, T., Obata, S., Nakatani, A., Amano, Y., Hida, E., Nibu, K. I., & Inohara, H. (2022). Validation of epistaxis severity score for hereditary hemorrhagic telangiectasia in Japan. Auris, nasus, larynx, 49(3), 415–420. https://doi.org/10.1016/j.anl.2021.11.005
Disciplines
Medicine and Health Sciences
PubMedID
34857410
Department(s)
Department of Medicine
Document Type
Article