Pregnancy Outcomes in Women With Thalassemia Trait: A Multicenter Cohort Study.

Publication/Presentation Date

1-1-2025

Abstract

INTRODUCTION: Thalassemia trait generally has minimal clinical impact, but physiologic changes during pregnancy may increase the risk of anemia, transfusion requirements, and hypertensive disorders. Existing evidence on pregnancy outcomes in this population is limited, with some conflicting data. This study aims to evaluate pregnancy-related outcomes in patients with thalassemia trait using a large, multicenter database.

METHODS: For this retrospective cohort study, we used data from the TriNetX US Collaborative Network. Females aged 18-45 with ICD-10 codes indicating pregnancy (Z33.1, O00-O9A, Z34, or Z3A) were included. Patients with pregnancy and coexisting thalassemia trait (D56.3) were assigned to the thalassemia cohort (

RESULTS: Thalassemia trait was associated with higher risks of anemia during pregnancy (RR: 3.00 and 95% CI: 2.87-3.13), needing blood transfusion (RR: 1.90 and 95% CI: 1.69-2.20), preeclampsia/eclampsia (RR: 1.54 and 95% CI: 1.47-1.61), cesarean delivery (RR: 1.43 and 95% CI: 1.36-1.51), preterm delivery < 37 weeks (RR: 1.40 and 95% CI: 1.31-1.65), and IUGR (RR: 1.96 and 95% CI: 1.72-2.23), all were statistically significant with a

CONCLUSION: Thalassemia trait in pregnancy was associated with increased rates of anemia, transfusion, and adverse maternal and fetal outcomes. Such adverse outcomes include pre-eclampsia/eclampsia, cesarean delivery, preterm birth and IUGR. These findings underscore the need for tailored peripartum care strategies in this high-risk population.

Volume

2025

First Page

8899690

Last Page

8899690

ISSN

2090-1267

Disciplines

Medicine and Health Sciences

PubMedID

41476858

Department(s)

Department of Medicine

Document Type

Article

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