Cystic fibrosis and pregnancy in the modern era: a case control study.
Publication/Presentation Date
1-1-2014
Abstract
BACKGROUND: Increasingly, women with cystic fibrosis become pregnant. Outcomes of these women need further study particularly in the setting of improved survival in CF.
METHODS: We performed a case-control study of pregnant CF women including 22 matched pairs with an average follow-up of 4.5 years. Nutritional outcomes, changes in lung function, and exacerbation rates were compared.
RESULTS: Matched pairs were similar in age, sweat chloride, FEV1 and FVC % predicted, BMI, and diabetes status. Change in BMI, FEV1 and FVC % predicted at the end of pregnancy and at last follow-up were similar between groups. Moreover, rates of exacerbation before, during and after pregnancy were similar. On multivariable analysis pregnancy had no effect on change in lung function over the study period. Significant predictors of decline included higher pre-pregnancy lung function and pancreatic insufficiency.
CONCLUSIONS: Pregnancy does not lead to immediate or medium-term adverse effects for CF patients.
Volume
13
Issue
1
First Page
69
Last Page
73
ISSN
1873-5010
Published In/Presented At
Ahluwalia, M., Hoag, J. B., Hadeh, A., Ferrin, M., & Hadjiliadis, D. (2014). Cystic fibrosis and pregnancy in the modern era: a case control study. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 13(1), 69–73. https://doi.org/10.1016/j.jcf.2013.08.004
Disciplines
Medicine and Health Sciences
PubMedID
24018176
Department(s)
Department of Medicine
Document Type
Article