A Fatal Case of Lisinopril-Induced Acute Necrotizing Pancreatitis.
Publication/Presentation Date
6-1-2023
Abstract
Angiotensin-converting enzyme inhibitors (ACE-I), such as lisinopril, are used as first-line therapy in the treatment of hypertension, heart failure with reduced ejection fraction, and proteinuric chronic kidney disease due to their beneficial effects on reducing morbidity and mortality. Commonly cited adverse effects of lisinopril include hyperkalemia, acute kidney injury, and angioedema, and while uncommon, there have been reports of lisinopril-induced necrotizing pancreatitis in the literature. The true incidence of drug-induced pancreatitis is unknown since establishing a causal relationship between medication's adverse effects and disease occurrence is difficult; however, there are validated tools such as the Adverse Drug Reaction Probability Scale that can aid in determining causality. Here, we present a case of a 63-year-old man with a history of hypertension who was being treated with lisinopril for eight months and developed a fatal case of lisinopril-induced severe necrotizing pancreatitis.
Volume
15
Issue
6
First Page
40071
Last Page
40071
ISSN
2168-8184
Published In/Presented At
Masarweh, O. M., Al-Moussally, F., Meruvia Garron, J. P., Kunadia, A., Karasik, O., & Asmar, A. (2023). A Fatal Case of Lisinopril-Induced Acute Necrotizing Pancreatitis. Cureus, 15(6), e40071. https://doi.org/10.7759/cureus.40071
Disciplines
Medicine and Health Sciences
PubMedID
37304386
Department(s)
Department of Medicine
Document Type
Article