Lack of effect of naloxone on prolactin and seizures in electroconvulsive therapy.
Publication/Presentation Date
1-1-1989
Abstract
Both opiate agonist and antagonist injection have been reported to modulate prolactin secretion, alter brain excitability and produce seizures, and modify the postictal state. We studied the effects of administration of high-dose naloxone, an opiate antagonist, on postictal prolactin levels, seizure duration, and postictal behavior, using patients undergoing electroconvulsive therapy (ECT) as a seizure model. Seven patients had 8 mg naloxone injected prior to one ECT treatment and saline injected prior to another treatment, with the order of injection randomized. Before ECT and 15 min after ECT, prolactin levels were drawn, and no blunting of the expected postictal prolactin elevation by naloxone injection was observed. We found no evidence that endogenous opiates trigger prolactin secretion during seizures. Seizure duration was also similar in saline and naloxone groups, and naloxone did not reverse postictal depression, as has been reported in an animal model.
Volume
30
Issue
1
First Page
41
Last Page
44
ISSN
0013-9580
Published In/Presented At
Sperling, M. R., Melmed, S., McAllister, T., & Price, T. R. (1989). Lack of effect of naloxone on prolactin and seizures in electroconvulsive therapy. Epilepsia, 30(1), 41–44. https://doi.org/10.1111/j.1528-1157.1989.tb05278.x
Disciplines
Medicine and Health Sciences
PubMedID
2912716
Department(s)
Department of Medicine
Document Type
Article