The effect of limbic and extralimbic electrical stimulations upon prolactin secretion in humans.
Publication/Presentation Date
4-23-1986
Abstract
The effect that extra-hypothalamic regions of the brain have upon prolactin secretion in humans was evaluated by performing electrical stimulations. Thirty-nine stimulations were performed, 22 to basolateral amygdala, 12 to hippocampus and 5 to orbitofrontal, supplementary motor and cingulate cortex. Only two stimulations causing high-frequency widespread limbic afterdischarges were followed by significant prolactin elevation. Four low-frequency afterdischarges involving amygdala and anterior hippocampus, one amygdala stimulus-dependent discharge and 19 amygdala, 8 hippocampal and 5 frontal sub-afterdischarge threshold stimulations had no prolactin elevation. These results fail to replicate earlier studies. We suggest that there is no evidence that the amygdala regulates serum prolactin within physiologic ranges, but that the regulation of prolactin may depend primarily upon other sub-cortical structures.
Volume
371
Issue
2
First Page
293
Last Page
297
ISSN
0006-8993
Published In/Presented At
Sperling, M. R., & Wilson, C. L. (1986). The effect of limbic and extralimbic electrical stimulations upon prolactin secretion in humans. Brain research, 371(2), 293–297. https://doi.org/10.1016/0006-8993(86)90365-3
Disciplines
Medicine and Health Sciences
PubMedID
3697759
Department(s)
Department of Medicine
Document Type
Article