Strong paired pulse depression of dentate granule cells in slices from patients with temporal lobe epilepsy.
Publication/Presentation Date
1-1-1998
Abstract
Recurrent, feedback excitation by sprouted mossy fibers may contribute to the hyperexcitability observed in human temporal lobe epilepsy. Observations in rodent models of epilepsy mimic the findings in human tissue and reveal that dentate granule cells sprout axons which innervate fibers in their own dendritic layer. However, recent evidence in rodents suggest that these sprouted fibers may form connections which cause inhibition of dentate granule cells, not excitation. Thus, the net effect of sprouting in human epileptic tissue may not only be recurrent excitation. We analyzed paired pulse depression in dentate slices from 9 patients with temporal lobe epilepsy and found evidence for strong feedback inhibition. We also noted failure of high frequency stimulation induced inhibition in our human specimens. These data challenge the concept that human epileptic dentate granule cells are excited by recurrent mossy fiber sprouting.
Volume
105
Issue
6-7
First Page
613
Last Page
625
ISSN
0300-9564
Published In/Presented At
Swanson, T. H., Sperling, M. R., & O'Connor, M. J. (1998). Strong paired pulse depression of dentate granule cells in slices from patients with temporal lobe epilepsy. Journal of neural transmission (Vienna, Austria : 1996), 105(6-7), 613–625. https://doi.org/10.1007/s007020050083
Disciplines
Medicine and Health Sciences
PubMedID
9826106
Department(s)
Department of Medicine
Document Type
Article