Lack of association between an interleukin 1 beta (IL-1beta) gene variation and refractory temporal lobe epilepsy.
Publication/Presentation Date
6-1-2001
Abstract
PURPOSE: We attempted to confirm recent findings of Kanemoto et al. that demonstrated a positive association (p < 0.017) between a polymorphism in the promoter region of the interleukin 1-beta (IL-1beta) gene and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS).
METHODS: We determined the frequency of this polymorphism in a group of 61 TLE+HS patients of European ancestry and compared it with that found in 119 ethnically matched control subjects.
RESULTS: Analysis of genotype and allele frequencies showed no statistically significant difference in the distribution of the polymorphism between the two groups (p = 0.10).
CONCLUSIONS: These data suggest that this IL-1beta promoter polymorphism does not act as a strong susceptibility factor for TLE+HS in a population of individuals of European ancestry.
Volume
42
Issue
6
First Page
782
Last Page
784
ISSN
0013-9580
Published In/Presented At
Buono, R. J., Ferraro, T. N., O'Connor, M. J., Sperling, M. R., Ryan, S. G., Scattergood, T., Mulholland, N., Gilmore, J., Lohoff, F. W., & Berrettini, W. H. (2001). Lack of association between an interleukin 1 beta (IL-1beta) gene variation and refractory temporal lobe epilepsy. Epilepsia, 42(6), 782–784. https://doi.org/10.1046/j.1528-1157.2001.42900.x
Disciplines
Medicine and Health Sciences
PubMedID
11422336
Department(s)
Department of Medicine
Document Type
Article