The effect of seizure severity on quality of life in epilepsy.
Publication/Presentation Date
9-1-2007
Abstract
Seizure severity is an important aspect of epilepsy. The relationship between seizure severity and quality of life in epilepsy, however, has been incompletely explored. With a data set of 118 women from the baseline phase of a clinical treatment trial, the relationship between seizure severity and aspects of quality of life was evaluated. Two domains of the Quality of Life in Epilepsy-31 (QOLIE-31) correlated highly significantly with seizure severity: Seizure Worry (r=-0.265, P=.004) and Social Functioning (r=-0.280, P=0.002). Two additional domains were significantly correlated: Overall Quality of Life (r=-0.210, P=0.023) and Cognitive (r=-0.209, P=0.024). When the potentially confounding effect of depression, measured by the Beck Depression Inventory, was controlled for, the regression of seizure severity with QOLIE-31 Seizure Worry remained significant (P=0.006, R(2)=0.153), as did the regression with QOLIE-31 Social Functioning (P=0.002, R(2)=0.184) and the regression with QOLIE-31 Cognitive (P=0.037, R(2)=0.30). These findings indicate that severe and potentially injurious seizure behaviors contribute to anxiety and socially avoidant behavior for persons with intractable epilepsy.
Volume
11
Issue
2
First Page
208
Last Page
211
ISSN
1525-5050
Published In/Presented At
Harden, C. L., Maroof, D. A., Nikolov, B., Fowler, K., Sperling, M., Liporace, J., Pennell, P., Labar, D., & Herzog, A. (2007). The effect of seizure severity on quality of life in epilepsy. Epilepsy & behavior : E&B, 11(2), 208–211. https://doi.org/10.1016/j.yebeh.2007.05.002
Disciplines
Medicine and Health Sciences
PubMedID
17604229
Department(s)
Department of Medicine
Document Type
Article