Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy.

Authors

• Falk W Lohoff
• Thomas N Ferraro
• John P Dahl
• Marie A Hildebrandt
• Theresa M Scattergood
• Michael J O'Connor
• Michael R Sperling
• Dennis J Dlugos
• Wade H Berrettini
• Russell J Buono

Publication/Presentation Date

1-1-2005

Abstract

Recently, an association between the C240T polymorphism in the brain-derived neurotrophic factor (BDNF) gene and partial epilepsy was demonstrated in a Japanese population. In this study we attempted to replicate the initial finding in a patient-control population of European ancestry and in addition tested whether the functional Val66Met polymorphism is associated with temporal lobe epilepsy (TLE). Genotypes of 151 TLE patients and 189 controls did not differ significantly for either of the variations. Results suggest that neither of the studied polymorphisms are strong susceptibility factors for TLE in this sample of individuals of European ancestry.

Volume

66

Issue

1-3

First Page

59

Last Page

62

ISSN

0920-1211

Published In/Presented At

Lohoff, F. W., Ferraro, T. N., Dahl, J. P., Hildebrandt, M. A., Scattergood, T. M., O'Connor, M. J., Sperling, M. R., Dlugos, D. J., Berrettini, W. H., & Buono, R. J. (2005). Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy. Epilepsy research, 66(1-3), 59–62. https://doi.org/10.1016/j.eplepsyres.2005.06.005

Disciplines

Medicine and Health Sciences

PubMedID

16105728

Department(s)

Department of Medicine

Document Type

Article