Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy.
Publication/Presentation Date
8-1-2020
Abstract
Because hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine genetic overlap between these conditions. First, we showed no significant genetic correlation, also when binned on minor allele frequency. Second, we confirmed the absence of polygenic overlap using genomic risk score analysis. Finally, we did not identify pleiotropic variants in meta-analyses of the 2 diseases. Our findings indicate that amyotrophic lateral sclerosis and epilepsy do not share common genetic risk, showing that hyper-excitability in both disorders has distinct origins.
Volume
92
First Page
1
Last Page
153
ISSN
1558-1497
Published In/Presented At
Schijven, D., Stevelink, R., McCormack, M., van Rheenen, W., Luykx, J. J., Koeleman, B. P. C., Veldink, J. H., Project MinE ALS GWAS Consortium, & International League Against Epilepsy Consortium on Complex Epilepsies (2020). Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy. Neurobiology of aging, 92, 153.e1–153.e5. https://doi.org/10.1016/j.neurobiolaging.2020.04.011
Disciplines
Medicine and Health Sciences
PubMedID
32409253
Department(s)
Department of Medicine
Document Type
Article