Reactivated Spatial Context Guides Episodic Recall.
Publication/Presentation Date
3-4-2020
Abstract
The medial temporal lobe (MTL) is known as the locus of spatial coding and episodic memory, but the interaction between these cognitive domains as well as the extent to which they rely on common neurophysiological mechanisms is poorly understood. Here, we use intracranial electroencephalography and a hybrid spatial-episodic memory task (29 subjects, 15 female) to determine how spatial information is dynamically reactivated in subregions of the human MTL and how this reactivation guides recall of episodic information. Our results implicate theta oscillations across the MTL as a common neurophysiological substrate for spatial coding in navigation and episodic recall. We further show that our index of retrieved spatial context is high in the hippocampus (HC) in an early time window preceding recall. Closer to recall, it decreases in the HC and increases in the parahippocampal gyrus. Finally, we demonstrate that hippocampal theta phase modulates parahippocampal gamma amplitude during retrieval of spatial context, suggesting a role for cross-frequency coupling in coding and transmitting retrieved spatial information.
Volume
40
Issue
10
First Page
2119
Last Page
2128
ISSN
1529-2401
Published In/Presented At
Herweg, N. A., Sharan, A. D., Sperling, M. R., Brandt, A., Schulze-Bonhage, A., & Kahana, M. J. (2020). Reactivated Spatial Context Guides Episodic Recall. The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(10), 2119–2128. https://doi.org/10.1523/JNEUROSCI.1640-19.2019
Disciplines
Medicine and Health Sciences
PubMedID
31974207
Department(s)
Department of Medicine
Document Type
Article