Proposal for an updated seizure classification framework in clinical trials.

Authors

• Claude Steriade
• Michael R Sperling
• Bree DiVentura
• Meryl Lozano
• Renée A Shellhaas
• Sudha Kilaru Kessler
• Dennis Dlugos
• Jacqueline French

Publication/Presentation Date

3-1-2022

Abstract

The International League Against Epilepsy (ILAE) seizure classification scheme has been periodically updated to improve its reliability and applicability to clinicians and researchers alike. Here, members of the Epilepsy Study Consortium propose a pragmatic seizure classification, based on the ILAE scheme, designed for use in clinical trials with a focus on outcome measures that have high reliability, broad interpretability across stakeholders, and clinical relevance in the context of the development of novel antiseizure medications. Controversies around the current ILAE classification scheme are discussed in the context of clinical trials, and pragmatic simplifications to the existing scheme are proposed, for intended use by investigators, industry sponsors, and regulatory agencies.

Volume

63

Issue

3

First Page

565

Last Page

572

ISSN

1528-1167

Published In/Presented At

Steriade, C., Sperling, M. R., DiVentura, B., Lozano, M., Shellhaas, R. A., Kessler, S. K., Dlugos, D., & French, J. (2022). Proposal for an updated seizure classification framework in clinical trials. Epilepsia, 63(3), 565–572. https://doi.org/10.1111/epi.17120

Disciplines

Medicine and Health Sciences | Physical Sciences and Mathematics

PubMedID

34997581

Department(s)

Department of Medicine

Document Type

Article