Genetic Variation in

Authors

• Russell J Buono
• Jonathan P Bradfield
• Zhi Wei
• Michael R Sperling
• Dennis J Dlugos
• Michael D Privitera
• Jacqueline A French
• Warren Lo
• Patrick Cossette
• Steven C Schachter
• Heather Basehore
• Falk W Lohoff
• Struan F A Grant
• Thomas N Ferraro
• Hakon Hakonarson

Publication/Presentation Date

9-18-2021

Abstract

We performed a genome-wide association study (GWAS) to identify genetic variation associated with common forms of idiopathic generalized epilepsy (GE) and focal epilepsy (FE). Using a cohort of 2220 patients and 14,448 controls, we searched for single nucleotide polymorphisms (SNPs) associated with GE, FE and both forms combined. We did not find any SNPs that reached genome-wide statistical significance (

Volume

12

Issue

9

ISSN

2073-4425

Published In/Presented At

Buono, R. J., Bradfield, J. P., Wei, Z., Sperling, M. R., Dlugos, D. J., Privitera, M. D., French, J. A., Lo, W., Cossette, P., Schachter, S. C., Basehore, H., Lohoff, F. W., Grant, S. F. A., Ferraro, T. N., & Hakonarson, H. (2021). Genetic Variation in PADI6-PADI4 on 1p36.13 Is Associated with Common Forms of Human Generalized Epilepsy. Genes, 12(9), 1441. https://doi.org/10.3390/genes12091441

Disciplines

Medicine and Health Sciences

PubMedID

34573423

Department(s)

Department of Medicine

Document Type

Article