Uncovering the biological basis of control energy: Structural and metabolic correlates of energy inefficiency in temporal lobe epilepsy.
Publication/Presentation Date
11-11-2022
Abstract
Network control theory is increasingly used to profile the brain's energy landscape via simulations of neural dynamics. This approach estimates the control energy required to simulate the activation of brain circuits based on structural connectome measured using diffusion magnetic resonance imaging, thereby quantifying those circuits' energetic efficiency. The biological basis of control energy, however, remains unknown, hampering its further application. To fill this gap, investigating temporal lobe epilepsy as a lesion model, we show that patients require higher control energy to activate the limbic network than healthy volunteers, especially ipsilateral to the seizure focus. The energetic imbalance between ipsilateral and contralateral temporolimbic regions is tracked by asymmetric patterns of glucose metabolism measured using positron emission tomography, which, in turn, may be selectively explained by asymmetric gray matter loss as evidenced in the hippocampus. Our investigation provides the first theoretical framework unifying gray matter integrity, metabolism, and energetic generation of neural dynamics.
Volume
8
Issue
45
First Page
2293
Last Page
2293
ISSN
2375-2548
Published In/Presented At
He, X., Caciagli, L., Parkes, L., Stiso, J., Karrer, T. M., Kim, J. Z., Lu, Z., Menara, T., Pasqualetti, F., Sperling, M. R., Tracy, J. I., & Bassett, D. S. (2022). Uncovering the biological basis of control energy: Structural and metabolic correlates of energy inefficiency in temporal lobe epilepsy. Science advances, 8(45), eabn2293. https://doi.org/10.1126/sciadv.abn2293
Disciplines
Medicine and Health Sciences
PubMedID
36351015
Department(s)
Department of Medicine
Document Type
Article