Direct brain recordings suggest a causal subsequent-memory effect.
Publication/Presentation Date
5-24-2023
Abstract
Endogenous variation in brain state and stimulus-specific evoked activity can both contribute to successful encoding. Previous studies, however, have not clearly distinguished among these components. We address this question by analysing intracranial EEG recorded from epilepsy patients as they studied and subsequently recalled lists of words. We first trained classifiers to predict recall of either single items or entire lists and found that both classifiers exhibited similar performance. We found that list-level classifier output-a biomarker of successful encoding-tracked item presentation and recall events, despite having no information about the trial structure. Across widespread brain regions, decreased low- and increased high-frequency activity (HFA) marked successful encoding of both items and lists. We found regional differences in the hippocampus and prefrontal cortex, where in the hippocampus HFA correlated more strongly with item recall, whereas, in the prefrontal cortex, HFA correlated more strongly with list performance. Despite subtle differences in item- and list-level features, the similarity in overall classification performance, spectral signatures of successful recall and fluctuations of spectral activity across the encoding period argue for a shared endogenous process that causally impacts the brain's ability to learn new information.
Volume
33
Issue
11
First Page
6891
Last Page
6901
ISSN
1460-2199
Published In/Presented At
Rubinstein, D. Y., Weidemann, C. T., Sperling, M. R., & Kahana, M. J. (2023). Direct brain recordings suggest a causal subsequent-memory effect. Cerebral cortex (New York, N.Y. : 1991), 33(11), 6891–6901. https://doi.org/10.1093/cercor/bhad008
Disciplines
Medicine and Health Sciences
PubMedID
36702495
Department(s)
Department of Medicine
Document Type
Article