Functional and anatomical connectivity predict brain stimulation's mnemonic effects.

Authors

• Youssef Ezzyat
• James E Kragel
• Ethan A Solomon
• Bradley C Lega
• Joshua P Aronson
• Barbara C Jobst
• Robert E Gross
• Michael R Sperling
• Gregory A Worrell
• Sameer A Sheth
• Paul A Wanda
• Daniel S Rizzuto
• Michael J Kahana

Publication/Presentation Date

1-14-2024

Abstract

Closed-loop direct brain stimulation is a promising tool for modulating neural activity and behavior. However, it remains unclear how to optimally target stimulation to modulate brain activity in particular brain networks that underlie particular cognitive functions. Here, we test the hypothesis that stimulation's behavioral and physiological effects depend on the stimulation target's anatomical and functional network properties. We delivered closed-loop stimulation as 47 neurosurgical patients studied and recalled word lists. Multivariate classifiers, trained to predict momentary lapses in memory function, triggered the stimulation of the lateral temporal cortex (LTC) during the study phase of the task. We found that LTC stimulation specifically improved memory when delivered to targets near white matter pathways. Memory improvement was largest for targets near white matter that also showed high functional connectivity to the brain's memory network. These targets also reduced low-frequency activity in this network, an established marker of successful memory encoding. These data reveal how anatomical and functional networks mediate stimulation's behavioral and physiological effects, provide further evidence that closed-loop LTC stimulation can improve episodic memory, and suggest a method for optimizing neuromodulation through improved stimulation targeting.

Volume

34

Issue

1

ISSN

1460-2199

Published In/Presented At

Ezzyat, Y., Kragel, J. E., Solomon, E. A., Lega, B. C., Aronson, J. P., Jobst, B. C., Gross, R. E., Sperling, M. R., Worrell, G. A., Sheth, S. A., Wanda, P. A., Rizzuto, D. S., & Kahana, M. J. (2024). Functional and anatomical connectivity predict brain stimulation's mnemonic effects. Cerebral cortex (New York, N.Y. : 1991), 34(1), bhad427. https://doi.org/10.1093/cercor/bhad427

Disciplines

Medicine and Health Sciences

PubMedID

38041253

Department(s)

Department of Medicine

Document Type

Article