Mapping Individualized Dual-Axis Network Topology in Focal Epilepsy: Divergent Alterations in System Integrity, Integration, and Clinical Correlates.
Publication/Presentation Date
3-19-2026
Abstract
Focal epilepsy is increasingly recognized as a disorder of distributed brain systems, yet characterizations of patient-specific alterations in network organization that are clinically meaningful remain limited. Here, we used resting-state functional MRI to introduce an overlap-permitting individualized network-estimation framework anchored to normative references to derive two complementary, system-level axes of topology: (1) network correspondence, indexing the expression of canonical networks and the fidelity of intrinsic system boundaries, and (2)
ISSN
2692-8205
Published In/Presented At
Zhang, Q., Dascal, A., Javidi, S. S., Ankeeta, A., Sperling, M. R., Zhang, Z., & Tracy, J. I. (2026). Mapping Individualized Dual-Axis Network Topology in Focal Epilepsy: Divergent Alterations in System Integrity, Integration, and Clinical Correlates. bioRxiv : the preprint server for biology, 2026.03.17.712432. https://doi.org/10.64898/2026.03.17.712432
Disciplines
Medicine and Health Sciences
PubMedID
41889982
Department(s)
Department of Medicine
Document Type
Article