High-gamma and beta bursts in the Left Supramarginal Gyrus can accurately differentiate verbal memory states and performance.
Publication/Presentation Date
6-28-2024
Abstract
The left supramarginal gyrus (LSMG) may mediate attention to memory, and gauge memory state and performance. We performed a secondary analysis of 142 verbal delayed free recall experiments, in patients with medically-refractory epilepsy with electrode contacts implanted in the LSMG. In 14 of 142 experiments (in 14 of 113 patients), the cross-validated convolutional neural networks (CNNs) that used 1-dimensional(1-D) pairs of convolved high-gamma and beta tensors, derived from the LSMG recordings, could label recalled words with an area under the receiver operating curve (AUROC) of greater than 60% [range: 60-90%]. These 14 patients were distinguished by: 1) higher amplitudes of high-gamma bursts; 2) distinct electrode placement within the LSMG; and 3) superior performance compared with a CNN that used a 1-D tensor of the broadband recordings in the LSMG. In a pilot study of 7 of these patients, we also cross-validated CNNs using paired 1-D convolved high-gamma and beta tensors, from the LSMG, to: a) distinguish word encoding epochs from free recall epochs [AUC 0.6-1]; and distinguish better performance from poor performance during delayed free recall [AUC 0.5-0.86]. These experiments show that bursts of high-gamma and beta generated in the LSMG are biomarkers of verbal memory state and performance.
Published In/Presented At
Sawczuk, N., Rubinstein, D. Y., Sperling, M. R., Wendel-Mitoraj, K., Djuric, P., Slezak, D. F., Kamienkowski, J., & Weiss, S. A. (2024). High-gamma and beta bursts in the Left Supramarginal Gyrus can accurately differentiate verbal memory states and performance. medRxiv : the preprint server for health sciences, 2024.05.29.24308117. https://doi.org/10.1101/2024.05.29.24308117
Disciplines
Medicine and Health Sciences
PubMedID
38853875
Department(s)
Department of Medicine
Document Type
Article