High-gamma and beta bursts in the left supramarginal gyrus can differentiate verbal memory states and performance.

Publication/Presentation Date

1-1-2025

Abstract

INTRODUCTION: The left supramarginal gyrus (LSMG) contributes to attentional allocation for memory encoding and may also reflect memory state and performance. Given the roles of high-gamma and beta bursts in cognition and memory, this proof-of-concept study investigated whether these signals within the LSMG could classify memory state and performance.

METHODS: Using secondary data from 103 epilepsy patients undergoing presurgical iEEG evaluation, we analyzed 141 delayed verbal free recall experiments. Intracranial EEG (iEEG) data, recorded solely from LSMG electrode contacts, were processed to create two-dimensional (2D) tensors of convolved high-gamma (HG), and beta (15-40 Hz) burst activity. Convolutional neural networks (CNNs) were trained and cross-validated on these 2D tensors to classify memory state (encoding versus recall) and performance (remembered versus forgotten items) within subjects.

RESULTS: The latter CNN, used to label subsequently recalled words based on iEEG recorded during the encoding epoch, performed at or below chance in 79 of the 141 experiments. In all but 3 of these 79 experiments, the iEEG was contaminated or low amplitude. In the other 62 experiments this CNN labeled recalled words with an area under the receiver operating curve (AUROC) score of greater than 0.52. A generalized linear model explained the variance of the AUROC score for labelling recalled words correctly in these 62 experiments (

DISCUSSION: This work indicates LSMG is a memory hotspot and that HG and beta bursts may serve as temporal memory information packets or signify attention related to memory.

Volume

16

First Page

1627528

Last Page

1627528

ISSN

1664-2295

Disciplines

Medicine and Health Sciences

PubMedID

40823292

Department(s)

Department of Medicine

Document Type

Article

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