Acute Kidney Injury and Outcomes in the Cardiac Intensive Care Unit: Insights from the Critical Care Cardiology Trials Network.
Publication/Presentation Date
4-9-2026
Abstract
BackgroundAcute kidney injury (AKI) is associated with high morbidity and mortality in critically ill patients. Multicenter analyses describing the epidemiology of AKI in the cardiac intensive care unit (CICU) are scarce. Here, we describe the prevalence, predictors, and outcomes associated with AKI in a contemporary multicenter CICU population.MethodsThe Critical Care Cardiology Trials Network (CCCTN) is a collaboration of CICUs in North America coordinated by the TIMI Study Group (Boston, MA). We evaluated patient and hospital-level outcomes as a function of creatinine-only Kidney Disease: Improving Global Outcomes (KDIGO) AKI stage within the CCCTN registry. Logistic regression was used to assess associations with in-hospital mortality.ResultsAmong 21 603 admissions, the overall prevalence of AKI was 23.7%, which was composed of KDIGO stage 1: 12.7%, stage 2: 1.7%, and stage 3: 9.2%. A higher prevalence and severity of AKI were seen in patients with baseline kidney disease, hypertension, or diabetes and in admissions with heart failure, cardiogenic shock, and cardiac arrest (
First Page
8850666261440201
Last Page
8850666261440201
ISSN
1525-1489
Published In/Presented At
Singam, N. S. V., Padkins, M., Papolos, A. I., Kenigsberg, B. B., Berg, D., Katz, J. N., van Diepen, S., Steverson, A. K., Rose, S. W., Wang, J., Bohula, E. A., Park, J. G., Morrow, D. A., Barsness, G. W., & Jentzer, J. C. (2026). Acute Kidney Injury and Outcomes in the Cardiac Intensive Care Unit: Insights from the Critical Care Cardiology Trials Network. Journal of intensive care medicine, 8850666261440201. Advance online publication. https://doi.org/10.1177/08850666261440201
Disciplines
Medicine and Health Sciences
PubMedID
41954488
Department(s)
Department of Medicine
Document Type
Article