Packed red blood cell transfusion in the intensive care unit: limitations and consequences.
Publication/Presentation Date
1-1-2007
Abstract
OBJECTIVE: To review the literature on the limitations and consequences of packed red blood cell transfusions, with particular attention to critically ill patients.
METHODS: The PubMed database of the National Library of Medicine was searched to find published articles on the indications, clinical utility, limitations, and consequences of red blood cell transfusion, especially in critically ill patients.
RESULTS: Several dozen papers were reviewed, including case series, meta-analyses, and retrospective and prospective studies evaluating the physiological effects, clinical efficacy, and consequences and complications of transfusion of packed red blood cells. Most available data indicate that packed red blood cells have a very limited ability to augment oxygen delivery to tissues. In addition, the overwhelming preponderance of data accumulated in the past decade indicate that patients receiving such transfusions have significantly poorer outcomes than do patients not receiving such transfusions, as measured by a variety of parameters including, but not limited to, death and infection.
CONCLUSIONS: According to the available data, transfusion of packed red blood cells should be reserved only for situations in which clear physiological indicators for transfusion are present.
Volume
16
Issue
1
First Page
39
Last Page
48
ISSN
1062-3264
Published In/Presented At
Gould, S., Cimino, M. J., & Gerber, D. R. (2007). Packed red blood cell transfusion in the intensive care unit: limitations and consequences. American journal of critical care : an official publication, American Association of Critical-Care Nurses, 16(1), 39–49.
Disciplines
Medicine and Health Sciences
PubMedID
17192525
Department(s)
Department of Medicine
Document Type
Article