Idiopathic pulmonary fibrosis patients with severe physiologic impairment: characteristics and outcomes.
Publication/Presentation Date
1-6-2021
Abstract
RESEARCH QUESTION: There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional characteristics as well as outcomes of patients with severe physiologic impairment.
PATIENTS AND METHODS: IPF patients with severe physiologic impairment defined by FVC ≤ 50% and/or DLco ≤ 30% predicted evaluated in the Inova Advanced Lung Disease Program between 2011 and 2019 were included. Demographic, physiologic, functional treatment and outcome data were collated.
RESULTS: There were 531 patients with IPF evaluated of whom 242 (46%) had severe physiologic impairment. Mean age was 72 ± 8 years; baseline FVC was 53 ± 17% and DL
CONCLUSION: IPF patients often present with severe physiologic impairment which may be poorly correlated with their functional status. Assessment of IPF disease severity should not be based on physiologic impairment alone, but should also encompass functional status as well as need for supplemental oxygen. Antifibrotic therapy in patients with severe physiologic impairment is associated with improved outcomes.
Volume
22
Issue
1
First Page
5
Last Page
5
ISSN
1465-993X
Published In/Presented At
Pastre, J., Barnett, S., Ksovreli, I., Taylor, J., Brown, A. W., Shlobin, O. A., Ahmad, K., Khangoora, V., Aryal, S., King, C. S., & Nathan, S. D. (2021). Idiopathic pulmonary fibrosis patients with severe physiologic impairment: characteristics and outcomes. Respiratory research, 22(1), 5. https://doi.org/10.1186/s12931-020-01600-z
Disciplines
Medicine and Health Sciences
PubMedID
33407450
Department(s)
Department of Medicine
Document Type
Article