Ticagrelor Removal From Human Blood.
Publication/Presentation Date
4-1-2017
Abstract
The authors devised an efficient method for ticagrelor removal from blood using sorbent hemadsorption. Ticagrelor removal was measured in 2 sets of in vitro experiments. The first set was a first-pass experiment using bovine serum albumin (BSA) solution pre-incubated with ticagrelor, whereas the second set, performed in a recirculating manner, used human blood mixed with ticagrelor. Removal of ticagrelor from BSA solution reached values >99%. The peak removal rate was 99% and 94% from whole blood and 99.99% and 90% from plasma during 10 h and 3 to 4 h of recirculating experiments, respectively. In conclusion, hemadsorption robustly removes ticagrelor from BSA solution and human blood samples.
Volume
2
Issue
2
First Page
135
Last Page
145
ISSN
2452-302X
Published In/Presented At
Angheloiu, G. O., Gugiu, G. B., Ruse, C., Pandey, R., Dasari, R. R., & Whatling, C. (2017). Ticagrelor Removal From Human Blood. JACC. Basic to translational science, 2(2), 135–145. https://doi.org/10.1016/j.jacbts.2017.01.007
Disciplines
Medicine and Health Sciences
PubMedID
30167561
Department(s)
Department of Medicine, Cardiology Division
Document Type
Article