In vitro catheter and sorbent-based method for clearance of radiocontrast material during cerebral interventions.
Publication/Presentation Date
1-1-2013
Abstract
BACKGROUND: Contrast-induced acute kidney injury is a severe condition resulting from the use of radiology contrast in patients with predisposing factors.
HYPOTHESIS: We hypothesized that a novel system including a device containing polymer resin sorbent beads and a custom-made suctioning catheter could efficiently remove contrast from an in vitro novel model of circulatory system (MOCS) mimicking the cerebral circulation.
METHODS: A custom-made catheter was built and optimized for cerebral venous approach. The efficiency of a system made of a polymer resin sorbent beads column (CST 401, Cytosorbents) and this particular catheter was tested in the MOCS running a solution composed of 0.9% saline and radio-contrast. During two series of 18 cycles of first-pass experiments we assessed the catheter's suctioning efficiency and the system's ability to clear radio-contrast injected into the MOCS's cerebral arterial segment. We also assessed the functioning and reliability of the MOCS.
RESULTS: Mean suctioning efficiency of the catheter was 84% ± 24%. The polymer sorbent column contrast removal rate was initially 96% and gradually decreased with subsequent cycles in a linear fashion during an experiment lasting approximately 90 minutes. The MOCS had a reliability of 0.9946×min(-1) where 1 × min(-1) was the optimum value.
CONCLUSION: A system including a polymer resin sorbent beads column and a custom-made suctioning catheter had an excellent initial efficiency in quickly removing contrast from an artificial MOCS mimicking the cerebral circulation. MOCS is an inexpensive and relatively reliable custom-made system that can be used for training or testing purposes.
Volume
14
Issue
4
First Page
207
Last Page
212
ISSN
1878-0938
Published In/Presented At
Angheloiu, G. O., Hänscheid, H., Reiners, C., Anderson, W. D., & Kellum, J. A. (2013). In vitro catheter and sorbent-based method for clearance of radiocontrast material during cerebral interventions. Cardiovascular revascularization medicine : including molecular interventions, 14(4), 207–212. https://doi.org/10.1016/j.carrev.2013.03.001
Disciplines
Medicine and Health Sciences
PubMedID
23665118
Department(s)
Department of Medicine, Cardiology Division
Document Type
Article