Recent advances in the understanding of endothelial barrier function and fluid therapy.
Publication/Presentation Date
1-26-2018
Abstract
Elucidation of the structural basis of endothelial barrier function and the study of transcapillary fluid exchange dynamics are areas of active research. There has been significant enhancement in our understanding of the ultrastructural basis of endothelial barrier function. The role of glycocalyx has received special attention. Experimental evidence has called for a revision in the classic Starling principle of transcapillary exchange. The glycocalyx model provides a potential structural mechanism for the revised Starling principle. This knowledge can provide the framework for understanding the volume expansion effect of fluid therapy and the physiological basis of fluid therapy.
Volume
94
Issue
111
First Page
289
Last Page
295
ISSN
1469-0756
Published In/Presented At
Thind, G. S., Zanders, S., & Baker, J. K. (2018). Recent advances in the understanding of endothelial barrier function and fluid therapy. Postgraduate Medical Journal, 94(111), 289-295. doi:10.1136/postgradmedj-2017-135125
Disciplines
Medical Sciences | Medicine and Health Sciences
PubMedID
29374091
Department(s)
Department of Medicine, Department of Medicine Fellows and Residents
Document Type
Article