Sertraline-associated syndrome of inappropriate antidiuretic hormone: case report and review of the literature.

Authors

Mary E. Bradley Pharm.D
Edward F. Foote Pharm.D
Edwin N. Lee MDFollow
Larry N. Merkle MD, FACP, Lehigh Valley Health NetworkFollow

Publication/Presentation Date

7-1-1996

Abstract

Selective serotonin reuptake inhibitors have gained widespread use in the treatment of depression. A 78-year-old woman became hyponatremic 3 days after being treated with sertraline and was subsequently diagnosed with the syndrome of inappropriate antidiuretic hormone (SIADH). She became symptomatic, but experienced rapid resolution of the laboratory and clinical abnormalities associated with SIADH on discontinuing sertraline and receiving fluid restriction, hypertonic saline, and demeclocycline. Several mechanisms may relate SIADH and vasopressin release to serotonin.

Volume

16

Issue

4

First Page

680

Last Page

683

ISSN

0277-0008

Published In/Presented At

Bradley, M. E., Foote, E. F., Lee, E. N., & Merkle, L. (1996). Sertraline-associated syndrome of inappropriate antidiuretic hormone: case report and review of the literature. Pharmacotherapy, 16(4), 680–683.

PubMedID

8840376

Department(s)

Department of Medicine, Department of Medicine Faculty

Document Type

Article