Pembrolizumab: An Immunotherapeutic Agent Causing Endocrinopathies.
Pembrolizumab is an immune checkpoint inhibitor (programmed cell death 1) approved for use in non-small cell lung carcinoma (NSCLC). Pembrolizumab has shown remarkable results in regression of the size of tumors in NSCLC and has shown survival advantage. However, immune-related adverse effects are a serious negative outcome of therapy. The number of immune-related adverse effects with pembrolizumab has increased significantly over the recent past. We present a case of type 1 diabetes mellitus and autoimmune thyroiditis with pembrolizumab treatment for NSCLC.
Published In/Presented At
Chaudry, A., Chaudry, M., & Aslam, J. (2020). Pembrolizumab: An Immunotherapeutic Agent Causing Endocrinopathies. Cureus, 12(6), e8836. https://doi.org/10.7759/cureus.8836
Medicine and Health Sciences
Peer Reviewed for front end display
Department of Medicine, Hematology-Medical Oncology Division