Intravascular Lymphoma with Progressive CNS Hemorrhage and Multiple Dissections.
Publication/Presentation Date
1-1-2020
Abstract
INTRODUCTION: Intravascular lymphoma (IVL) is an uncommon and often fatal disease characterized by intraluminal proliferation of lymphomatous cells within blood vessels. Because of a heterogeneous clinical presentation and lack of sensitive diagnostic protocols, diagnosis of IVL is most often made at autopsy. However, with early diagnosis and appropriate chemotherapy, the prognosis is greatly improved and complete remission is possible. In order to broaden the possible presentations of IVL, we present a patient with an atypical manifestation of biopsy-proven intravascular large B-cell lymphoma who suffered dissections of both intracranial and extracranial arteries in addition to progressive intracranial hemorrhages.
CONCLUSION: IVL is known to exert its pathology on small arteries and capillaries, but is not known to cause dissections of large vessels. The diagnosis should be considered in cases with unexplained arterial dissections and progressive strokes. Early diagnosis with appropriate laboratory screening and tissue confirmation by biopsy can lead to greatly improved outcomes.
Volume
2020
First Page
6134830
Last Page
6134830
ISSN
2090-6668
Published In/Presented At
Chen, R., Singh, G., McNally, J. S., Palmer, C. A., & de Havenon, A. (2020). Intravascular Lymphoma with Progressive CNS Hemorrhage and Multiple Dissections. Case reports in neurological medicine, 2020, 6134830. https://doi.org/10.1155/2020/6134830
Disciplines
Medicine and Health Sciences
PubMedID
32547798
Department(s)
Department of Medicine
Document Type
Article