A prospective, head-to-head comparison of 2 EUS-guided liver biopsy needles in vivo.
Publication/Presentation Date
5-1-2021
Abstract
BACKGROUND AND AIMS: Procedural standardization in endoscopic ultrasound-guided liver biopsy (EUS-LB) is necessary to obtain core biopsy specimens for accurate diagnosis. The objective of this study was to directly compare the diagnostic yield of 2 EUS-LB fine-needle biopsy (FNB) systems in vivo.
METHODS: In this prospective, single-center study, 108 adult patients undergoing EUS-LB over a 1-year period were included. Each EUS-LB consisted of an EGD, followed by EUS-guided biopsy of the left lobe of the liver sequentially using 2 different 19-gauge needles: the fork-tip (SharkCore) and Franseen (Acquire) FNB systems. Specimens were then reviewed by a GI histopathologist to determine diagnostic adequacy as well as the number of complete portal tracts, specimen length, and degree of fragmentation.
RESULTS: In 79.4% of cases, the fork-tip FNB system yielded a final diagnosis compared with 97.2% of the Franseen FNB specimens (P < .001). The mean number of complete portal tracts in the fork-tip FNB samples was 7.07 compared with 9.59 in the Franseen FNB samples (P < .001). The mean specimen length was 13.86 mm for the fork-tip FNB and 15.81 mm for the Franseen FNB (P = .004). Cores were intact in 47.6% of the fork-tip FNB samples and in 75.2% of the Franseen FNB samples (P = .004).
CONCLUSIONS: In EUS-LB, we found that the 19-gauge Franseen FNB system resulted in a statistically significant increase in diagnostic adequacy compared with biopsy using the fork-tip FNB system.
Volume
93
Issue
5
First Page
1133
Last Page
1138
ISSN
1097-6779
Published In/Presented At
Aggarwal, S. N., Magdaleno, T., Klocksieben, F., MacFarlan, J. E., Goonewardene, S., Zator, Z., Shah, S., & Shah, H. N. (2021). A prospective, head-to-head comparison of 2 EUS-guided liver biopsy needles in vivo. Gastrointestinal endoscopy, 93(5), 1133–1138. https://doi.org/10.1016/j.gie.2020.09.050
Disciplines
Gastroenterology | Pathology
PubMedID
33045222
Department(s)
Department of Medicine, Department of Pathology and Laboratory Medicine, Network Office of Research and Innovation
Document Type
Article