Association of Adiponectin and Vitamin D With Tumor Infiltrating Lymphocytes and Survival in Stage III Colon Cancer.
Publication/Presentation Date
10-1-2021
Abstract
Background: Adipocyte-derived adiponectin may play a role in the host inflammatory response to cancer. We examined the association of plasma adiponectin with the density of tumor-infiltrating lymphocytes (TILs) in colon cancers and with vitamin D, clinicopathological features, and patient survival.
Methods: Plasma adiponectin and 25-hydroxyvitamin D [25(OH)D] were analyzed by radioimmunoassay in 600 patients with stage III colon cancer who received FOLFOX-based adjuvant chemotherapy (NCCTG N0147 [Alliance]). TIL densities were determined in histopathological sections. Associations with disease-free survival (DFS), time to recurrence, and overall survival were evaluated by multivariable Cox regression adjusting for potential confounders (ie, body mass index, race, TILs, and N stage). All statistical tests were 2-sided.
Results: We found a statistically significant reduction in adiponectin, but not 25(OH)D, levels in tumors with high vs low TIL densities (median
Conclusions: Lower circulating adiponectin levels were associated with a statistically significant increase in TIL densities in colon cancers, indicating an enhanced antitumor immune response. In contrast to TILs, neither adiponectin nor 25(OH)D was independently prognostic.
Volume
5
Issue
5
ISSN
2515-5091
Published In/Presented At
Sinicrope, F. A., Shi, Q., Smyrk, T. C., Goldberg, R. M., Cohen, S. J., Gill, S., Kahlenberg, M. S., Nair, S., Shield, A. F., Jahagirdar, B. N., Jacobson, S. B., Foster, N. R., Pollak, M. N., & Alberts, S. R. (2021). Association of Adiponectin and Vitamin D With Tumor Infiltrating Lymphocytes and Survival in Stage III Colon Cancer. JNCI cancer spectrum, 5(5), pkab070. https://doi.org/10.1093/jncics/pkab070
Disciplines
Medicine and Health Sciences
PubMedID
34485815
Department(s)
Department of Medicine
Document Type
Article