Effect of surface coating on platelet count drop during cardiopulmonary bypass.
Publication/Presentation Date
5-1-1999
Abstract
This study was designed to investigate the effect of surface coating on platelet count drop during cardiopulmonary bypass (CPB). Sixty patients undergoing open-heart surgery were randomly divided into three groups each receiving a different type of coated hollow-fiber membrane oxygenator. The patients were given either an uncoated oxygenator (noncoated group), an oxygenator coated with Carmeda (Carmeda group) or an uncoated oxygenator with albumin in the priming solution (albumin group). Comparisons were made in platelet count pre-CPB, on bypass (15-25 min) and during the warming period. Calculations were used to account for the effect of hemodilution. The albumin group had significantly lower platelet count drops (-4.8+/-7.1%) than the Carmeda group (11.0+/-8.3%) and the noncoated group (20.3+/-14.5%). Carmeda surface coating demonstrated some beneficial effects, but to a lesser degree than the albumin.
Volume
14
Issue
3
First Page
195
Last Page
200
ISSN
0267-6591
Published In/Presented At
Palanzo DA, Zarro DL, Manley NJ, Montesano RM, Quinn M, Gustafson PA. Effect of surface coating on platelet count drop during cardiopulmonary bypass. Perfusion. 1999 May;14(3):195-200. doi: 10.1177/026765919901400307. PMID: 10411249.
Disciplines
Medicine and Health Sciences
PubMedID
10411249
Department(s)
Department of Medicine
Document Type
Article