Reflux Disease and Laryngeal Neoplasia in Nonsmokers and Nondrinkers.
Publication/Presentation Date
9-1-2020
Abstract
Gastroesophageal reflux disease (GERD) has been hypothesized as a risk factor for development of laryngeal cancer. A case-control study was performed to assess the association of laryngeal neoplasia with GERD. Cases consisted of patients with a history of laryngeal cancer or carcinoma in situ. Controls were patients without neoplasia who matched cases 2:1 on age, sex, race, and smoking history. Univariate and multivariate analyses were performed to assess risk of laryngeal neoplasia and GERD. In total, 2094 patients were included. Cases had higher rates of GERD. Univariate analysis demonstrated a positive association between GERD and laryngeal neoplasia (odds ratio, 1.33; 95% CI, 1.07-1.64). Multivariate analysis controlling for alcohol use history also demonstrated a positive association between GERD and laryngeal neoplasia (adjusted odds ratio, 1.29; 95% CI, 1.04-1.59). These results suggest increased odds of laryngeal carcinoma and carcinoma in situ in patients with GERD when controlling for smoking and drinking history.
Volume
163
Issue
3
First Page
560
Last Page
562
ISSN
1097-6817
Published In/Presented At
Parsel, S. M., Iarocci, A. L., Gastañaduy, M., Winters, R. D., Marino, J. P., & McCoul, E. D. (2020). Reflux Disease and Laryngeal Neoplasia in Nonsmokers and Nondrinkers. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 163(3), 560–562. https://doi.org/10.1177/0194599820917669
Disciplines
Medicine and Health Sciences
PubMedID
32340545
Department(s)
Department of Medicine, Department of Surgery, Division of Otolaryngology
Document Type
Article
Comments
Presented at the AAO-HNSF Annual Meeting: New Orleans, LA, September 2019.