Application of goal-directed therapy for the use of concentrated antithrombin for heparin resistance during cardiac surgery.
Publication/Presentation Date
3-1-2021
Abstract
The maintenance of anticoagulation in adult patients undergoing cardiopulmonary bypass is dependent upon a number of factors, including heparin concentration and adequate antithrombin activity. Inadequate anticoagulation increases the risk of thrombosis and jeopardizes both vascular and extracorporeal circuit integrity. The purpose of this study was to evaluate a goal-directed approach for the use of antithrombin in patients who were resistant to heparin. Following institutional review board approval, data were obtained from quality improvement records. A goal-directed protocol for antithrombin was established based upon heparin dosing (400 IU kg
Volume
36
Issue
2
First Page
171
Last Page
182
ISSN
1477-111X
Published In/Presented At
Stammers, A. H., Francis, S. G., Miller, R., Nostro, A., Tesdahl, E. A., & Mongero, L. B. (2021). Application of goal-directed therapy for the use of concentrated antithrombin for heparin resistance during cardiac surgery. Perfusion, 36(2), 171–182. https://doi.org/10.1177/0267659120926089
Disciplines
Medicine and Health Sciences
PubMedID
32536326
Department(s)
Department of Medicine
Document Type
Article