Application of goal-directed therapy for the use of concentrated antithrombin for heparin resistance during cardiac surgery.

Publication/Presentation Date

3-1-2021

Abstract

The maintenance of anticoagulation in adult patients undergoing cardiopulmonary bypass is dependent upon a number of factors, including heparin concentration and adequate antithrombin activity. Inadequate anticoagulation increases the risk of thrombosis and jeopardizes both vascular and extracorporeal circuit integrity. The purpose of this study was to evaluate a goal-directed approach for the use of antithrombin in patients who were resistant to heparin. Following institutional review board approval, data were obtained from quality improvement records. A goal-directed protocol for antithrombin was established based upon heparin dosing (400 IU kg

Volume

36

Issue

2

First Page

171

Last Page

182

ISSN

1477-111X

Disciplines

Medicine and Health Sciences

PubMedID

32536326

Department(s)

Department of Medicine

Document Type

Article

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