Catching the Zebra: Clinical Pearls and Pitfalls for the Successful Diagnosis of Zollinger-Ellison Syndrome.
Publication/Presentation Date
9-1-2017
Abstract
Zollinger-Ellison syndrome (ZES) results from an ectopic gastrin-secreting tumor leading to peptic ulcer disease, reflux, and chronic diarrhea. While early recognition portends an excellent prognosis with >80% survival at 15 years, symptoms are often nonspecific making the diagnosis difficult to establish. Diagnosis involves a series of tests, including fasting gastrin, gastric pH, chromogranin A, and secretin stimulation. Performing these tests in the correct sequence and at the proper time is essential to avoid inaccurate results. Tumor localization is equally nuanced. Although providers have classically used
Volume
62
Issue
9
First Page
2258
Last Page
2265
ISSN
1573-2568
Published In/Presented At
Mendelson, A. H., & Donowitz, M. (2017). Catching the Zebra: Clinical Pearls and Pitfalls for the Successful Diagnosis of Zollinger-Ellison Syndrome. Digestive diseases and sciences, 62(9), 2258–2265. https://doi.org/10.1007/s10620-017-4695-7
Disciplines
Medicine and Health Sciences
PubMedID
28776139
Department(s)
Department of Medicine
Document Type
Article