Insights into the genetic risk factors for the development of pancreatic disease.
Publication/Presentation Date
3-1-2017
Abstract
Diseases of the exocrine pancreas such as recurrent acute pancreatitis (RAP), chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) represent syndromes defined according to traditional clinicopathologic criteria. The failure of traditional approaches to identify primary mechanisms underlying these progressive disorders illustrates a greater problem of failure of the germ theory of disease for complex disorders. Multiple genetic discoveries and new complex disease models force consideration of a new paradigm of 'precision medicine', requiring a new mechanistic definition of CP. Recognizing the advances in understanding complex gene and environment interactions, as well as the development of new strategies that limit or prevent the development of devastating end-stage diseases of the pancreas may lead to substantial improvements in patient care.
Volume
10
Issue
3
First Page
323
Last Page
336
ISSN
1756-283X
Published In/Presented At
Zator, Z., & Whitcomb, D. C. (2017). Insights into the genetic risk factors for the development of pancreatic disease. Therapeutic advances in gastroenterology, 10(3), 323–336. https://doi.org/10.1177/1756283X16684687
Disciplines
Medicine and Health Sciences
PubMedID
28246549
Department(s)
Department of Medicine
Document Type
Article