Beyond tissue plasminogen activator: mechanical intervention in acute stroke.
Publication/Presentation Date
6-1-2003
Abstract
Mechanical interventions in acute ischemic stroke promise to provide emergency physicians with tools to treat patients in whom conventional thrombolysis might be ineffective or contraindicated, including most patients with stroke who arrive at the emergency department beyond the 3-hour time window for intravenous tissue plasminogen activator. A systematic MEDLINE literature review was performed. Endovascular interventions currently in early human clinical trials include the use of lasers, ultrasonography, angioplasty, microsnares, and a variety of clot-retrieval devices. Potential advantages of these approaches include more rapid recanalization of occluded vessels, reduced or no exposure to fibrinolytic agents, and a longer treatment window. Early safety trials are promising, with serial improvements in device design to minimize trauma to cerebrovascular endothelium and accelerate vessel recanalization. The purpose of this review is to provide the emergency medicine community with an understanding of these promising and emerging approaches to acute stroke therapy.
Volume
41
Issue
6
First Page
838
Last Page
846
ISSN
0196-0644
Published In/Presented At
Leary, M. C., Saver, J. L., Gobin, Y. P., Jahan, R., Duckwiler, G. R., Vinuela, F., Kidwell, C. S., Frazee, J., & Starkman, S. (2003). Beyond tissue plasminogen activator: mechanical intervention in acute stroke. Annals of emergency medicine, 41(6), 838–846. https://doi.org/10.1067/mem.2003.194
Disciplines
Medicine and Health Sciences
PubMedID
12764340
Department(s)
Department of Medicine
Document Type
Article