A Novel Approach to Understanding Pathogenesis and Treatment of Capillary Dropout in Retinal Vascular Diseases.
Publication/Presentation Date
3-1-2016
Abstract
Capillary dropout is a common sequela of endothelial cell dysfunction that underlies the pathology of multiple retinal vascular diseases, including familial exudative vitreoretinopathy (FEVR). Wide-field fluorescein angiography allowed for identification of areas of capillary inflammatory changes and late-phase angiographic posterior and peripheral vascular leakage (LAPPEL). We propose LAPPEL as a precursor in pathogenesis of capillary dropout and a marker of endothelial cell inflammation in the retina. The authors describe a case of FEVR with significant macular edema associated with LAPPEL, which was successfully treated with topical and intravitreal steroids. The implication for disease mechanism and potential future treatment applications are also discussed.
Volume
47
Issue
3
First Page
288
Last Page
292
ISSN
2325-8179
Published In/Presented At
Thanos, A., Todorich, B., & Trese, M. T. (2016). A Novel Approach to Understanding Pathogenesis and Treatment of Capillary Dropout in Retinal Vascular Diseases. Ophthalmic surgery, lasers & imaging retina, 47(3), 288–292. https://doi.org/10.3928/23258160-20160229-14
Disciplines
Medicine and Health Sciences
PubMedID
26985805
Department(s)
Department of Medicine
Document Type
Article