Regression of prostate cancer following administration of Genistein Combined Polysaccharide (GCP), a nutritional supplement: a case report.
Publication/Presentation Date
8-1-2002
Abstract
PURPOSE: It has been reported that genistein, an isoflavone used in soybeans, has antiprostate cancer effects. Genistein Combined Polysaccharide (GCP trade mark; AMino Up, Sapporo, Japan), a nutritional supplement manufactured in Japan, is composed of genistein and a polysaccharide obtained from basidiomycetes (mycelia) that grows in a variety of mushrooms.
METHODS: We report a case of a patient with a biopsy proven prostate cancer showing clinical and pathologic evidence of regression following administration of GCP. The patient was enrolled in an Institutional Review Board (IRB)-approved protocol and received GCP for 6 weeks prior to radical prostatectomy.
RESULTS: The patient's prostate-specific antigen (PSA) decreased from an initial value of 19.7 to 4.2 ng/mL after 44 days of low-dose GCP. No cancer was identified in the radical prostatectomy specimen and no side effects were observed in this patient.
CONCLUSION: This case suggests that GCP, which has shown potent inhibitory effects against prostate cancer in vitro, may have some potential activity in the treatment and prevention of prostate cancer.
Volume
8
Issue
4
First Page
493
Last Page
497
ISSN
1075-5535
Published In/Presented At
Ghafar, M. A., Golliday, E., Bingham, J., Mansukhani, M. M., Anastasiadis, A. G., & Katz, A. E. (2002). Regression of prostate cancer following administration of Genistein Combined Polysaccharide (GCP), a nutritional supplement: a case report. Journal of alternative and complementary medicine (New York, N.Y.), 8(4), 493–497. https://doi.org/10.1089/107555302760253694
Disciplines
Medicine and Health Sciences
PubMedID
12230910
Department(s)
Department of Medicine
Document Type
Article