Immune reconstitution inflammatory syndrome associated with biologic therapy.
Publication/Presentation Date
2-1-2015
Abstract
The use of biologics in the treatment of autoimmune disease, cancer, and other immune conditions has revolutionized medical care in these areas. However, there are drawbacks to the use of these medications including increased susceptibility to opportunistic infections. One unforeseen risk once opportunistic infection has occurred with biologic use is the onset of immune reconstitution inflammatory syndrome (IRIS) upon drug withdrawal. Although originally described in human immunodeficiency virus (HIV) patients receiving highly active antiretroviral therapy, it has become clear that IRIS may occur when recovery of immune function follows opportunistic infection in the setting of previous immune compromise/suppression. In this review, we draw attention to this potential pitfall on the use of biologic drugs.
Volume
15
Issue
2
First Page
499
Last Page
499
ISSN
1534-6315
Published In/Presented At
Gupta, M., Jafri, K., Sharim, R., Silverman, S., Sindher, S. B., Shahane, A., & Kwan, M. (2015). Immune reconstitution inflammatory syndrome associated with biologic therapy. Current allergy and asthma reports, 15(2), 499. https://doi.org/10.1007/s11882-014-0499-4
Disciplines
Medicine and Health Sciences
PubMedID
25504263
Department(s)
Department of Medicine
Document Type
Article